Figure 2.
![WM platelets respond appropriately to standard agonists. (A-B) OgFg binding and (C-D) P-selectin exposure in WB and PRP samples, respectively, from HDs (n = 7-14, blue), patients with WM not on therapy (n = 8-13, red), or receiving BTKis (n = 0-5, green). Representative histograms from a HD showing (A) OgFg- or (C) P-selectin–positive events. Data (mean ± standard deviation [SD]) for (B) OgFg binding or (D) P-selectin exposure (%) in platelets treated with 0.5, 5 or 30 μg/mL crosslinked CRP-XL, 10 μM TRAP-6, or 5 μM ADP. P values were determined by Mann-Whitney t test with multiple comparisons.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/8/21/10.1182_bloodadvances.2024014190/1/blooda_adv-2024-014190-gr2.jpeg?Expires=1733469448&Signature=xw2pWA36YrrmaoXrwgUIVLNPdiHBX~kAUvaWcdtnbNv-pmV7yaK-xbzvBIgcZn3I2oI8jIcInPvGLWACoGHWR-RIz-YcuTu4cekS-QsQp5gS2fa3NgsEjPj~LPne1P72HKQ7qOfTuZlPHFKm58lQImoyPfQmXUBdJ9S9tHgDDw~kBlnAo4zBqqOdAWNa1ej5sV92jv74h6niqAQdaYoYTNrV2KvolEQRS5GPunKR3ygO6kAdtxONa7wNuotS9vBJkcMZ3N4O8VQdE4FKoZH6n3rl-xk8g1gJal0jyhQFTdKtUXNRAv3xY63uxbriFRPYE37vUobDGwo7pqlxj4H~bQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
WM platelets respond appropriately to standard agonists. (A-B) OgFg binding and (C-D) P-selectin exposure in WB and PRP samples, respectively, from HDs (n = 7-14, blue), patients with WM not on therapy (n = 8-13, red), or receiving BTKis (n = 0-5, green). Representative histograms from a HD showing (A) OgFg- or (C) P-selectin–positive events. Data (mean ± standard deviation [SD]) for (B) OgFg binding or (D) P-selectin exposure (%) in platelets treated with 0.5, 5 or 30 μg/mL crosslinked CRP-XL, 10 μM TRAP-6, or 5 μM ADP. P values were determined by Mann-Whitney t test with multiple comparisons.
