S-G04, an enantiomer of R-G04, is more potent and able to improve in vivo platelet survival of cold-stored human platelets up to 10 days in a preclinical model. (A) Schematic experimental design for the in vivo preclinical model of platelet survival analysis. (B) Recovery of 7-day stored human platelets transfused in clodronate-treated, sublethally irradiated thrombocytopenic NSG immunodeficient mice. (C) AUC of data depicted in panel B. (D) Recovery of 10-day stored human platelets transfused in clodronate-treated, sublethally irradiated thrombocytopenic NSG immunodeficient mice. (E) AUC of panel D. For each experiment, data include a minimum of 6 mice per group in each of the 2 independent experiments. ∗∗∗P < .001.
Figure 6.

S-G04, an enantiomer of R-G04, is more potent and able to improve in vivo platelet survival of cold-stored human platelets up to 10 days in a preclinical model. (A) Schematic experimental design for the in vivo preclinical model of platelet survival analysis. (B) Recovery of 7-day stored human platelets transfused in clodronate-treated, sublethally irradiated thrombocytopenic NSG immunodeficient mice. (C) AUC of data depicted in panel B. (D) Recovery of 10-day stored human platelets transfused in clodronate-treated, sublethally irradiated thrombocytopenic NSG immunodeficient mice. (E) AUC of panel D. For each experiment, data include a minimum of 6 mice per group in each of the 2 independent experiments. ∗∗∗P < .001.

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