Analysis of GRNs in cells differentiated in presence of spCAR or spUTD. SimiC was applied to infer GRNs associated with more mature phenotypes or with those still in the differentiation process. (A) Heat map showing the regulatory dissimilarity score between cells exposed to spUTD and those exposed to spCAR of the different regulons within neutrophil lineage cells and monocytic lineage cells. (B) Histograms showing the activity score of KLF6 and CEBPB regulons, which are associated with neutrophilic lineage, and the IKZF1, MEF2C, and MAFB regulons, associated with monocytic lineage, for cells exposed to spUTD and those exposed to spCAR. (C) Representative scheme of cytokine-related genes that belong to the regulons KLF6, CEBPB, IKZF1, MEF2C, and MAFB. (D) Networks of the TFs KLF6, CEBPB, IKZF1, MEF2C, and MAFB and their top related genes.