![Manhattan plots of the association between SNPs and stable warfarin dose after pooling 6 African ancestry cohorts in a meta-analysis (n = 1504) and conditioning for well-established loci. Individual GWAS analyses were undertaken using logarithm transformed stable warfarin dose, adjusted for age, sex, weight, target INR range, simvastatin/amiodarone status, and either the first 10 principal components of genetic ancestry or the proportion of the specific ancestry per chromosome by frequentist association testing assuming an additive model of inheritance before being pooled using METAL. (A) Adjustment for VKORC1 -1639 G>A (genomic inflation factor = 1.023). (B) Adjustment for VKORC1 and rs12777823 (genomic inflation factor = 1.022). (C) Adjustment for VKORC1, rs12777823 and CYP2C9 (genomic inflation factor = 1.020). The red horizontal lines represent the genome-wide (5 × 10−8) significance thresholds. The top genes (obtained from a FUMA-GWAS [platform] gene-based Manhattan plot) per main loci are annotated. CYP2C9/18, cytochrome P450, family 2, subfamily C, polypeptide 9/18.](https://ash.silverchair-cdn.com/ash/content_public/journal/bloodadvances/8/20/10.1182_bloodadvances.2024014227/2/blooda_adv-2024-014227-gr4.jpeg?Expires=1734693291&Signature=qsSW2cVt1TmGcm69Ip5Nt9Y3NJcR7vR~DAMGUrO2bKHMQv6GY~zfhJVgOjLz6IVesV4Co5wiX8XsavXtOGF2mMQcLB79D85rMc8No3AMtY47zSESC3pO5aT3IzqLac4SUYlzU6Rd6-0QB3x7QWno~utmOZw~pEYVzmDQp-23yd5UKoLAg0p1NvtIXxAv56-G7fg0oEK6~g1Uf05KYNe-WFAWyayx-w8VAmSxvhd5kzGSywyTW5yaTyyke~C3m~Oh6PF4IjT5kULyS3cg77~4OHUhS-wQL5JdcuU-F96xChGmBtcTzVVU0NcLmjw~4CmrD91cP34bWRUE03QtyfNGLg__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Manhattan plots of the association between SNPs and stable warfarin dose after pooling 6 African ancestry cohorts in a meta-analysis (n = 1504) and conditioning for well-established loci. Individual GWAS analyses were undertaken using logarithm transformed stable warfarin dose, adjusted for age, sex, weight, target INR range, simvastatin/amiodarone status, and either the first 10 principal components of genetic ancestry or the proportion of the specific ancestry per chromosome by frequentist association testing assuming an additive model of inheritance before being pooled using METAL. (A) Adjustment for VKORC1 -1639 G>A (genomic inflation factor = 1.023). (B) Adjustment for VKORC1 and rs12777823 (genomic inflation factor = 1.022). (C) Adjustment for VKORC1, rs12777823 and CYP2C9 (genomic inflation factor = 1.020). The red horizontal lines represent the genome-wide (5 × 10−8) significance thresholds. The top genes (obtained from a FUMA-GWAS [platform] gene-based Manhattan plot) per main loci are annotated. CYP2C9/18, cytochrome P450, family 2, subfamily C, polypeptide 9/18.
