Risk of CNS recurrence in patients with HGBL, NOS based on blood or bone marrow involvement, CD5 expression, COO, and DEL phenotype and CNS-IPI. (A) Blood involvement; (B) bone marrow involvement; (C) CD5 expression; (D) non-GCB COO; (E) DEL phenotype; and (F) CNS-IPI. P values are from Gray’s test.