Anemia during treatment. Spaghetti plot of individual hemoglobin values. With lines representing the LLN for female (red dotted line) and male (blue dotted line) patients, along with lines representing CTC grade 2 anemia (black dotted line) and CTC grade 3 anemia (black full line). CTC, Common Terminology Criteria for Adverse Events; LLN, lower limit of normal.