Differential expression and pathway enrichment analysis of ABZB cell lines on RP11-350G8.5 KO. (A) Differential expression analysis: each point is a gene, significantly differentially expressed genes in RP11-350G8.5 KO vs SCRAMBLE (SCR) are highlighted, with top 10 differentially expressed ones in the insets. (B) Transcription factors differentially active in RP11-350G8.5 KO vs SCR computed by DoRothEA. (C-D) Gene Ontology (GO) BP Enrichment Analysis of the upregulated and downregulated genes. (E) Cnet plot details for the Reactome Pathway Enrichment Analysis of the downregulated genes.