Molecular profile of patients with MDS-del(5q) according to TP53 allelic state. Oncoplot showing the distribution of gene mutations in the 27 genes analyzed across all patients with NGS data (n = 626) in the different groups according to TP53 allelic state (TP53-wt, n = 501; TP53-mono, n = 94; TP53 multihit, n = 31). Mutational patterns did not exhibit significant differences among TP53-wt, TP53-monoallelic, and TP53-multihit patients. The most frequently mutated gene among this cohort was TP53 (20%), followed by SF3B1 (19%), DNMT3A (17%), TET2 (13%), ASXL1 (9%), and JAK2 (7%). The median number of mutations was 1 in each subgroup. Each column represents 1 patient. All 27 analyzed genes as well as the occurrence of del(5q) as a sole aberration or with 1 additional cytogenetic aberration are given for each patient and represented in rows. White represents wild type; blue, mutated (number of mutations are depicted in different shades of blue); light orange, isolated del(5q); and dark orange, del(5q) and 1 additional lesion.