Kaplan-Meier curves for OS and risk of AML evolution according to TP53 allelic state. (A) The median OS was 73.2 months (95% CI, 57.0-91.1) for TP53-monoallelic and 56.9 (95% CI, 42.7-133.9) for TP53-multihit patients (P = .33). (B) The risk of evolution to AML at 60 months was 25.5% for TP53-monoallelic and 40.4% for TP53-multihit patients (HR, 1.9; 95% CI, 1.0-3.7; P = .04).