Management of acute VTE in patients with brain cancer, without recent ICH².¹Noncontrast head CT or brain MRI with and without contrast for preanticoagulation baseline assessment, if no imaging within preceding 2 weeks. ²Recent ICH defined as imaging evidence of ICH in past 30 days. Hemosiderin residues (usually intratumoral) are not considered to be recent ICH. ³Discuss risk-benefit ratio of anticoagulation and alternatives with patient and/or health care proxy and document before treatment initiation. ⁴Isolated distal DVT refers to calf vein DVT without known PE (and without clinical suspicion of PE). ⁵Isolated subsegmental PE refers to isolated subsegmental PE and absence of DVT on bilateral lower extremity ultrasound doppler. ⁶Close observation without anticoagulation includes lower extremity ultrasound doppler after 1 week (consider repeat in 2 weeks) to exclude new DVT or proximal DVT progression. LE, lower extremity; UE, upper extremity.