Hypotheses for maladaptive mechanisms for ERG haploinsufficiency resulting in HMs. This figure illustrates the normal interactions of ERG as part of a heptad of TFs. Although ERG mutation can result in an adaptive somatic corrections (cnLOH), several suggested scenarios may lead to malignancy: maladaptive genomic corrections, abnormal interactions with other TFs, and the expression of aberrant ERG isoforms. Professional illustration by Somersault18:24.