NGS-based approach confirms and refines the historical classifier in adult T-ALL. (A) Comparison of CIR according to NGS- or Sanger-based method to identify NFRP classifier in adult T-ALL. At 5 years, CIR was 53% (95% CI, 39-64) in HR Sanger/HR NFRP NGS, 17% (95% CI, 10-26) in LR Sanger/LR NFRP NGS, 60% (95% CI, 7-91) (at 4.29 years, no longer follow-up) in LR Sanger/HR NFRP NGS, and 22% (95% CI, 3-53) in HR Sanger/LR NFRP NGS. (B) Comparison of OS according to NGS or Sanger-based method to identify NOTCH1/FBXW7/RAS/PTEN (NFRP) classifier in adult T-ALL. At 5 years, OS was 52% (95% CI, 41-66) in HR Sanger/HR NFRP NGS, 82% (95% CI, 73-91) in LR Sanger/LR NFRP NGS, 40% (95% CI, 14-100) in LR Sanger/HR NFRP NGS, and 78% (95% CI, 55-100) in HR Sanger/LR NFRP NGS.