Figure 3.
Impact of MYC break-apart FISH patterns on MYC and DZsig expression. (A) Proportion of tumors positive for MYC protein expression by IHC. P values are from Fisher exact tests. (B) MYC mRNA expression, as determined by digital gene expression profiling. P values are from t tests. Dotted lines indicate the mean MYC mRNA expression for the balanced (gray) and GCB DLBCL (orange) groups. (C) Proportion of tumors positive for DZsig, as determined by the DLBCL90 assay. P values are from χ2 tests. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001. ns, not significant; ref, reference group.
