MYC partner gene and rearrangement architecture in HGBCL-DH-BCL2 according to MYC break-apart FISH pattern. (A) Frequency of MYC rearrangement partners and break points relative to the MYC gene determined in whole-genome and/or capture sequencing. Rearrangement partners are grouped as IG (IGH, IGK, or IGL), recurrent non-IG (BCL6 or PAX5), other non-IG (all other partners), intrachromosomal, or not found. Intrachromosomal rearrangements were defined as structural events involving the MYC locus and another region of chromosome 8 >20kb away. Intragenic breaks occurring in intron 1 of MYC are included in the centromeric group. (B) MYC breakpoint location in tumors with LR and LG patterns, showing that the MYC gene is predicted to be on the derivative chromosome with the signal that is still present in almost all tumors.