Patterns of MYC break-apart FISH probe signals and their proportions in HGBCL-DH-BCL2. (A) Representative MYC break-apart FISH patterns. When the MYC locus is undisturbed, the red (centromeric) and green (telomeric) signals are in close proximity and produce a fused signal. An example of a rearrangement producing a balanced break-apart pattern is depicted using MYC and IGH as example loci. (B) Frequency of break-apart FISH patterns observed in 297 HGBCL-DH-BCL2 tumors. Balanced represents equal number of break-apart probe signals, whereas unbalanced gain indicates that both red and green break-apart signals are present but not equal in numbers.