KDM6A loss impact on chromatin structure. (A) Distribution of KDM6A binding sites annotated regions of the genome in ARP-1 cell lines. (B) Box plot showing the proportion of total enhancers and promoters bound by KDM6A. (C) H3K27ac-seq, H3k27me3-seq, and ATAC-seq (assay for transposase-accessible chromatin with sequencing) signals in ARP-1 isogenic clonal cell line WT or KO for KDM6A centered on H3K4me1 peaks for enhancers and centered on transcription start sites for promoters. (D) H3K27me3 metagene analysis at locus bound by KDM6A in ARP-1 isogenic clonal cell line WT or KO for KDM6A. (E) Genome browser view of the CIITA locus in ARP-1 cell line WT or KO for KDM6A. TES, transcription end site; TSS, transcription start site.
Figure 3.

KDM6A loss impact on chromatin structure. (A) Distribution of KDM6A binding sites annotated regions of the genome in ARP-1 cell lines. (B) Box plot showing the proportion of total enhancers and promoters bound by KDM6A. (C) H3K27ac-seq, H3k27me3-seq, and ATAC-seq (assay for transposase-accessible chromatin with sequencing) signals in ARP-1 isogenic clonal cell line WT or KO for KDM6A centered on H3K4me1 peaks for enhancers and centered on transcription start sites for promoters. (D) H3K27me3 metagene analysis at locus bound by KDM6A in ARP-1 isogenic clonal cell line WT or KO for KDM6A. (E) Genome browser view of the CIITA locus in ARP-1 cell line WT or KO for KDM6A. TES, transcription end site; TSS, transcription start site.

This Feature Is Available To Subscribers Only

or Create an Account

Close Modal
Close Modal