KDM6A monoallelic loss in female patients with myeloma corresponds with worse outcome. (A) Heat map of somatic copy number (CN) on the X chromosome for female patients with MM from CoMMpass. (B) Histogram of somatic CN for female patients. The red line denotes the threshold used for CN number loss and the number of female patients. (C) Expression of KDM6A in 703 patients with newly diagnosed MM from the CoMMpass trial with CN and RNA-sequencing data. P values determined by linear regression. (D) Progression-free survival for CoMMpass patients grouped into the categories shown in panel C. P values determined by Cox proportional hazards regression relative to the female (F; red) group. (E) Response of female patients with or without loss of the X chromosome, treated with lenalidomide or other regimens. SD, stable disease; PR partial response; VGPR, very good partial response; CR, complete response; sCR, stringent complete response (X2 test). FPKM, fragment per kilobase per million mapped fragment; M, male.