Structural diagram of RARA and RARG fusions. (A) Structural diagram of tripartite and bipartite RARA fusions in each RARA-aAPL case. A∗, unique patient number. (B) Red arrows indicate RARA 3′ splicing sites of each case. The purple background highlights the H11 (left) and H12 (right) coding regions. (C) Structure diagram of tripartite RARG fusion transcripts in each RARG-aAPL case. G∗, unique patient number. The 3′ end of each transcript extends to the first poly(A) signal. Crosshatched bars indicate UTRs; gray-filled bars indicate coding regions; and color-filled bars mark the DBD, LBD, and helices 11 (H11) and 12 (H12). The green background highlights the H11_12 coding region. Dark red dashed vertical lines indicate the splice sites. Bars are displayed proportionally according to their length. Bars with breaks indicate that the length of these segments is not to scale.
Figure 2.

Structural diagram of RARA and RARG fusions. (A) Structural diagram of tripartite and bipartite RARA fusions in each RARA-aAPL case. A∗, unique patient number. (B) Red arrows indicate RARA 3′ splicing sites of each case. The purple background highlights the H11 (left) and H12 (right) coding regions. (C) Structure diagram of tripartite RARG fusion transcripts in each RARG-aAPL case. G∗, unique patient number. The 3′ end of each transcript extends to the first poly(A) signal. Crosshatched bars indicate UTRs; gray-filled bars indicate coding regions; and color-filled bars mark the DBD, LBD, and helices 11 (H11) and 12 (H12). The green background highlights the H11_12 coding region. Dark red dashed vertical lines indicate the splice sites. Bars are displayed proportionally according to their length. Bars with breaks indicate that the length of these segments is not to scale.

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