KDM6A controls genes related to immune response in MM. (A) Dupéré-Richer et al show that KDM6A regulates transcription of MHC’s master regulatory genes CIITA and NLRC5 in multiple myeloma cells by promoting acetylation of enhancers. (B) KDM6A deficiency results in decreased MHC’s expression and T-cell infiltration. (C) HDAC3 inhibitor reinstates acetylation of histones together with MHC expression in KDM6A-deficient MM cells.