Plasma-derived VWF captured IgG in blood type O HCs. rVWF (VONVENDI) was compared with plasma-derived VWF (Humate-P) in the screening assay for their abilities to capture and bind IgG in the plasma of 51 and 41 HCs, respectively. Mann-Whitney tests were performed on the ODs between bound and detected IgG in blood group O individuals and non-O (A, B, and AB) individuals. There was no significant difference (NS) between O and non-O IgG levels when captured by rVWF but significantly increased IgG detection in type O vs non-O plasma applied to the plasma-derived VWF. ∗∗∗∗P ≤ .0001.