Outcome according to TRB::NOTCH1 fusion status in pediatric patients with T-LBL and T-ALL. (A) Six-year EFS according to TRB::NOTCH1 status. (B) Six-year CIR. (C) Distribution of genomic breakpoints in TRB and NOTCH1 in pediatric T-LBL. Vertical lines represent the observed breakpoints along the TRB (left) and NOTCH1 (right) loci. The sizes of the pin circles correlate with the absolute number of breakpoints in our cohort. Numerical labels indicate event counts associated with specific breakpoints. Corresponding sample numbers are indicated next to the pins. SE, standard error; w/o, without.