The distribution of DiR-labeled exosomes in vivo and its effect on bone lesion repair. (A) Biodistribution of DiR-labeled exosomes in LP-1 tumor bearing NSG mice. (B) Biodistribution of DiR-labeled exosomes in the heart, kidney, lung, liver and spleen of the mice. (C) Micro-CT image shown the bone destruction of the scapular. (D) The percentage of scapular bone destruction area in different treatment groups. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001; ∗∗∗∗P < .0001.