DMR analysis and corresponding pathways. Analysis of DMRs and methylation-based pathway analysis integrating RNA expression data in IgM gammopathies compared with normal controls (A,C) and WM compared with IgM-MGUS (B,D). DMR statistical analysis was conducted using the Pearson χ² analysis comparing expected with observed values to determine P value. AKT, protein kinase B; AMPK, AMP-activated protein kinase; ECM, extracellular matrix; EGF, epidermal growth factor; EIF, eukaryotic initiation factor; ERBB4, erb-b2 receptor tyrosine kinase 4; ERK, extracellular signal-regulated kinase; FAK, focal adhesion kinase; GM-CSF, granulocyte-macrophage colony-stimulating factor; IGF-1, insulin-like growth factor 1; ILK, integrin-linked kinase; MSP-RON, macrophage stimulating protein-recepteur d'origine nantais; PAK, p21 activated protein kinases; PD-1, programmed cell death protein; PDL-1, programmed death-ligand 1; PPAR, peroxisome proliferator-activated receptor; PTEN, phosphatase and tensin homolog; RXR, retinoid X receptor; TGF, transforming growth factor; Th1, T helper cell 1; TME, tumor microenvironment; VEGF, vascular endothelial growth factor.