VWF may contribute to disease pathobiology for a variety of both hemostatic and nonhemostatic disorders. Illustration of hemostatic disorders in which VWF has been implicated in playing a direct pathogenic role (left). Illustration of a series of nonhemostatic disorders in which putative pathogenic roles for VWF have been proposed (right). Some evidence suggests that VWF may potentially affect other types of diseases which are not included in this figure. CTEPH, chronic thromboembolic pulmonary hypertension; DVT, deep vein thrombosis; TTP, thromboembolic thrombocytopenic purpura.