VWF interacts with a variety of different cell types to influence both physiological and pathological processes. The diverse biological roles of VWF are mediated through effects upon ECs, neutrophils, leucocytes, macrophages, dendritic cells, tumor cells, smooth muscle cells, and osteoclasts as illustrated. VWF may potentially effect other types of cells which are not included in this figure. LRP4, low-density lipoprotein receptor–related protein 4; M0, undifferentiated macrophage; M1, proinflammatory macrophage; NETosis, formation of neutrophil extracellular traps; P38, protein kinase 38; Tie-2, tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2; FGD5, FYVE, RhoGEF, and PH domain–containing protein 5; VEGFR-2, vascular endothelial growth factor receptor 2.
Figure 3.

VWF interacts with a variety of different cell types to influence both physiological and pathological processes. The diverse biological roles of VWF are mediated through effects upon ECs, neutrophils, leucocytes, macrophages, dendritic cells, tumor cells, smooth muscle cells, and osteoclasts as illustrated. VWF may potentially effect other types of cells which are not included in this figure. LRP4, low-density lipoprotein receptor–related protein 4; M0, undifferentiated macrophage; M1, proinflammatory macrophage; NETosis, formation of neutrophil extracellular traps; P38, protein kinase 38; Tie-2, tyrosine kinase with immunoglobulin-like and epidermal growth factor-like domains 2; FGD5, FYVE, RhoGEF, and PH domain–containing protein 5; VEGFR-2, vascular endothelial growth factor receptor 2.

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