A broad spectrum of ligands interacts with VWF through binding sites across all its domains. VWF has been reported to interact with a wide variety of structurally diverse binding partners. The binding sites for some of these ligands has been localized to specific domains. This figure includes many but not all the reported VWF-ligands. The asterisk (∗) indicates growth factor interactions: VEGF-A165, PIGF-2, PDGF-AA/BB/CC/DD, FGF-2/7/18, TGF-β1, BMP-2, NGF-β, NT-3, and CXCL-12γ. ADAM28, A disintegrin and metalloproteinase 28; ApoA-I, apolipoprotein A-I; ASGPR, asialoglycoprotein receptor; β2-GPI, β2 glycoprotein I; BMP-2, bone morphogenetic protein 2; CCN2/CTGF, connective tissue growth factor; CTL-2, choline transporter-like protein 2; CXCL-12γ, C-X-C motif chemokine ligand 12 gamma; eNOS, endothelial nitric oxide synthase; HDL, high-density lipoprotein; HNPs, human neutrophil peptides; IGFBP7, insulin-like growth factor–binding protein 7; IL-8, interleukin-8; LDL, low-density lipoprotein; MGL, macrophage galactose lectin; NGF, nerve growth factor; NT-3, neurotrophin-3; PDGF, platelet-derived growth factor; PDIA1, protein disulfide isomerase A1; PF4, platelet factor 4; PIGF-2, placental growth factor-2; PolyP, polyphosphate; PSGL-1, P-selectin glycoprotein ligand-1; RANKL, RANK ligand; Siglec-5, sialic acid–binding immunoglobulin-like lectin 5; Slc44a2, solute carrier family 44 member 2; TGF, transforming growth factor.
Figure 2.

A broad spectrum of ligands interacts with VWF through binding sites across all its domains. VWF has been reported to interact with a wide variety of structurally diverse binding partners. The binding sites for some of these ligands has been localized to specific domains. This figure includes many but not all the reported VWF-ligands. The asterisk (∗) indicates growth factor interactions: VEGF-A165, PIGF-2, PDGF-AA/BB/CC/DD, FGF-2/7/18, TGF-β1, BMP-2, NGF-β, NT-3, and CXCL-12γ. ADAM28, A disintegrin and metalloproteinase 28; ApoA-I, apolipoprotein A-I; ASGPR, asialoglycoprotein receptor; β2-GPI, β2 glycoprotein I; BMP-2, bone morphogenetic protein 2; CCN2/CTGF, connective tissue growth factor; CTL-2, choline transporter-like protein 2; CXCL-12γ, C-X-C motif chemokine ligand 12 gamma; eNOS, endothelial nitric oxide synthase; HDL, high-density lipoprotein; HNPs, human neutrophil peptides; IGFBP7, insulin-like growth factor–binding protein 7; IL-8, interleukin-8; LDL, low-density lipoprotein; MGL, macrophage galactose lectin; NGF, nerve growth factor; NT-3, neurotrophin-3; PDGF, platelet-derived growth factor; PDIA1, protein disulfide isomerase A1; PF4, platelet factor 4; PIGF-2, placental growth factor-2; PolyP, polyphosphate; PSGL-1, P-selectin glycoprotein ligand-1; RANKL, RANK ligand; Siglec-5, sialic acid–binding immunoglobulin-like lectin 5; Slc44a2, solute carrier family 44 member 2; TGF, transforming growth factor.

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