Treatment outcomes for all the 185 treated patients. (A) Kaplan-Meier estimates of EFS and overall survival. (B) Comparison of the EFS through different periods of time: 1985 to 1999, 2000 to 2009, and since 2010. (C) Patterns of treatment failure: TRM, progressive cancer, and second malignancy. P values are based on a comparison performed at a predefined time point of 4 years from cancer diagnosis based on log-log transformation.