Sequencing treatments in LBCL. Flowchart outlines a proposed sequencing of therapies in LBCL based on current approvals and highlighting when to consider CAR T cells and/or BsAbs. GCB, germinal center B cell; Lonca, loncastuximab tesirine; PMBCL (primary mediastinal B-cell lymphoma); Pola-BR, polatuzumab vedotin, bendamustine rituximab; R-GemOx, rituximab, gemcitabine, oxaliplatin; Tafa/len, tafasitamab/lenalidomide.