Biodistribution and shedding profiles of each collected sample. (A) Median vector DNA biodistribution and shedding profiles in blood, saliva, semen, stool, and urine, and (B) median (min, max) encapsidated vector DNA biodistribution and shedding profiles in plasma and semen following an infusion of 6 × 10¹³ vg/kg valoctocogene roxaparvovec. Data were binned in 4-week intervals. Lines represent the median concentration of vector DNA (A). Solid lines represent the median concentration of encapsidated vector DNA. Dashed lines represent the min and max concentration levels of encapsidated vector DNA (B). wk, week.