Illustration and clinical impact of chromothripsis and gains at 6q27 affecting MLLT4 in T-ALL. (A) SNP array results indicating chromothripsis events in T-ALL, n = 6. (B) EFS according to the presence of chromothripsis in the whole cohort of T-ALL (P = .008). (C) CIR according to the presence of chromothripsis in the whole cohort of T-ALL (P < .001). (D) SNP array results indicating a duplication at 6q27 affecting MLLT4 in T-ALL, n = 10. (E) EFS according to the presence of a gain at 6q27 in the whole cohort of T-ALL (P = .01). (F) CIR according to the presence of a gain at 6q27 in the whole cohort of T-ALL (P = .07).