Comutation landscape of MDS with E592K or exon 14-16 SF3B1 mutations. All cases of SF3B1-mutant MDS that sequenced at least the 24 additional genes shown were included. Fisher exact test P values and Benjamini linear multiple testing q values for FDR < 0.05 were as follows: ∗∗∗∗ASXL1 = 1.13E-16 and 2.37E-15; ∗∗∗∗RUNX1 = 2.06E-10 and 2.16E-09; ∗∗∗∗STAG2 = 5.03E-08 and 3.52E-07; and ∗NRAS = 4.61E-03 and 2.42E-02.