Development of t(11:14) venetoclax-resistant clones from single cells. (A) A panel of t(11:14) MM cell lines were treated with several doses of venetoclax for 72 hours. Cell viability was assessed by CellTiter-Glo (CTG) and IC₅₀ was calculated using GraphPad prism. (B) Schema of development of DTEP/resistant clones. (C) Cell viability was evaluated using CTG after 72 hours of treatment with venetoclax in parental cells and clones and represented as percentage of viable cells compared with each untreated control. IC₅₀ is also shown.