Risk of any infection for C282Y homozygotes (C282Y/C282Y) compared with individuals noncarrier for both C282Y and H63D (noncarrier/noncarrier) stratified by levels of plasma iron, transferrin saturation, and ferritin at study enrollment. Normal iron was defined as iron from 9 to 34 μmol/L and high iron defined as iron >34 μmol/L. Normal transferrin saturation was defined as transferrin saturation from 10% to 45% for women aged <50 years and 15% to 45% for women aged >50 years and men regardless of age. High transferrin saturation was defined as transferrin saturation >45% regardless of sex and age. Normal ferritin was defined as ferritin from 12 to 200 μg/L for women and 12 to 300 μg/L for men. High ferritin was defined as ferritin >200 μg/L for women and >300 μg/L for men. Dots indicate hazard ratio; solid vertical lines indicate 95% CI. sat., saturation.