Figure 4.
Risk of pneumonia and sepsis according to levels of plasma iron, transferrin saturation, and ferritin. Solid red lines are hazard ratios, broken black lines indicate 95% CIs. Analyses were multivariable adjusted for age, year of birth, sex, smoking status, cumulative smoking in pack-years, alcohol consumption, body mass index, menopausal status, study cohort, Charlson comorbidity index, and level of C-reactive protein. Reference for the continuous models (splines) is the median value of plasma iron (14 μmol/L), transferrin saturation (23%), or ferritin (100 μg/L) in the respective analyses. All individuals who had a measurement of iron, transferrin saturation, or ferritin were included in the categorical analyses and in modeling of the splines, but when drawing the spline curves, the x-axis was capped at the 99.9th percentile. ref., reference.