Association between plasma sEPCR and CKD in patients with SCD. A cohort of patient samples (N = 35) from the Walk-PHaSST biorepository was subdivided into 2 groups: non-CKD and CKD. eGFR (A), uACR (B), and serum creatinine (C) in the indicated groups of patients with SCD. Level of plasma sEPCR (D) and TPH (E) showing elevated circulating EPCR and heme in the CKD group of patients with SCD. ∗∗P < .01; ∗∗∗P < .001 (unpaired Student t test).