Mean change from baseline to 2, 6, and 12 months for secondary HRQoL scales by treatment arm. Mean change from baseline and 95% CIs are displayed. Higher scores in emotional, cognitive and social functioning, global health/quality of life, maintaining purpose, and family support indicate better functioning/quality of life. Higher scores in fatigue, nausea/vomiting, dyspnea, insomnia, appetite loss, constipation, diarrhea, financial difficulties, mobility, worries about others, future worries, and joint stiffness indicate higher severity of symptoms/problems. DEC, decitabine.