A summary of the key results from Chen et al, in which kidney function was assessed in 10-month-old (Aged) mice with SCD as a decrease in glomerular filtration rate (GFR), increased uACR, increased uKIM1 levels, and decreased renal perfusion. Kidney injury was associated with increased sEPCR in plasma. In contrast, 4- to 6-week-old (Young) SCD mice had modest kidney injury, which was exacerbated by repeat doses of hemin. EPCR^OX reversed some markers of heme-induced kidney injury in young SCD mice. EPCR^OX, overexpression of endothelial protein C receptor; sEPCR, soluble endothelial protein C receptor; SCD, sickle cell disease; uACR, urinary albumin:creatinine ratio; uKIM1, urinary kidney injury molecule 1. Figure created with BioRender.com.