American Society of Hematology

Figure 3.

$PIM inhibitors synergize with splicing disruptors to kill AML cell lines. (A) MOLM16 and EOL-1 cells were treated with AZD1208 and SD6 or pladienolide B or each drug alone, at 5 concentrations (see supplemental Methods) in the ratios shown. (B) MLL-rearranged EOL-1 and MV4-11 cells were treated with PIM447 + SPHINX31 or each drug alone at 5 concentrations (see supplemental Methods) in the ratios shown. CI values were calculated using CompuSyn. Fa-CI plots were generated based on constant dose ratio drug combination data. CI < 1 indicates synergy; CI > 1 indicates antagonism; CI = 1 indicates additivity. The tan shaded area indicates synergy and strong effect (fraction affected, Fa > 0.75).$

PIM inhibitors synergize with splicing disruptors to kill AML cell lines. (A) MOLM16 and EOL-1 cells were treated with AZD1208 and SD6 or pladienolide B or each drug alone, at 5 concentrations (see supplemental Methods) in the ratios shown. (B) MLL-rearranged EOL-1 and MV4-11 cells were treated with PIM447 + SPHINX31 or each drug alone at 5 concentrations (see supplemental Methods) in the ratios shown. CI values were calculated using CompuSyn. Fa-CI plots were generated based on constant dose ratio drug combination data. CI < 1 indicates synergy; CI > 1 indicates antagonism; CI = 1 indicates additivity. The tan shaded area indicates synergy and strong effect (fraction affected, Fa > 0.75).

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