Single-cell DNA and RNA sequencing define cells carrying CH mutations. (A) Schematic showing experimental design. (B) UMAP showing cell types for cells from patient with TET2 CH-21-014. (C) UMAP showing mutational status for cells from patient with TET2 CH-21-014. (D) Stacked bar plot quantifying proportion of mutant cells per cell type for cells from patient with TET2 CH-21-014. (E) UMAP showing cell types for cells from patient with DNMT3A CH-20-046. (F) UMAP showing mutational status for cells from patient with DNMT3A CH-20-046. (G) Stacked bar plot quantifying proportion of mutant cells per cell type for cells from patient with DNMT3A CH-20-046. (H) UMAP showing predicted mutational status for cells from patient with TET2 CH-21-014, based on presence of MT mutation 7754G>C. (I) Stacked bar plot quantifying proportion of mutant cells per cell type for cells from patient with TET2 CH-21-014. (J) UMAP showing predicted mutational status for cells from patient with DNMT3A CH-20-046, based on presence of MT mutation 747A>G. (K) Stacked bar plot quantifying proportion of mutant cells per cell types for cells from patient with DNMT3A CH-20-046. NK, natural killer; SNVs, single nucleotide variant.