Specific EBV genome variants are enriched in or depleted from NKTCL. (A) Volcano plot demonstrating all variants identified. Variants above the horizontal red line indicate variants with a Bonferroni corrected P value <.05. Significant variants with log(OR) less than −1.5 are shown in red (lower risk), and log(OR) >1.5 in blue (higher risk). (B) Heat map demonstrating a correlation between variants significantly enriched in NKTCL–derived EBV genomes with log(OR) >1.5.