Phylogenetic analysis of reference, noncancer-associated, and cancer- associated EBV genomes. The inner circle represents the histology for cancer- associated genomes or other phenotype, the middle circle represents the country of origin, and the outer circle represents the region of origin. Genomes are aligned to the type I reference genome NC_007605 assembled from data for B95-8 (V01555) and Raji (M35547) genomes. CAEBV, chronic active EBV disease; GC, gastric cancer; IM, infectious mononucleosis; misc, miscellaneous; pLELC, primary lymphoepithelioma-like carcinoma; PTLD, posttransplant lymphoproliferative disorder.