Rev-erbα cross talk with RORα to regulates EPO gene expression. ChIP analysis was performed using chromatin isolated from HepG2 cells treated with DMOG (500 μM) and GSK4112 (30 μM) for 24 hours. Immuno-precipitation was performed with Rev-erbα and RORα antibodies at h-RRE1 (A-B) and h-RRE2 (C-D). (E) Schematic representation of the proposed mechanism underlying the modulation of EPO gene expression by Rev-erbα and RORα. Data are representative or mean ± SD from 3 independent experiments. ∗P < .05; ∗∗P < .01; ∗∗∗P < .001, compared with control or as indicated. CTRL, control.