Rev-erbα regulates EPO production in vivo. C57BL/6 mice treated with DMOG (6 hours) alone or in combination with Rev-erbα agonist SR9011 (24 hours) for 3 alternate days were investigated for relative mRNA expression (A-B) of EPO in the kidney (A) and liver (B), and serum EPO level (C) and a comparison of hematological parameters (n = 4) (D-E). ∗P < .05; ∗∗P < .01; ∗∗∗P < .0001, as indicated. MCH, mean corpuscular hemoglobin; MCHC, mean corpuscular hemoglobin concentration; MCV, mean corpuscular volume; MPV, mean platelet volume; PCT, plateletcrit; PDW, platelet distribution width; RDW, red blood cell distribution width.