Rev-erbα KO mice had altered RBC indices and increased EPO levels. A comparison of total blood counts in Rev-erbα KO and WT mice shows the values for RBCs, HGB, and HCT (A) and the number of white blood cells (WBCs) and platelets (PLTs) (B). (C) Serum EPO levels in Rev-erbα KO were compared with WT littermate controls. (D-E) qRT-PCR was used to determine the relative EPO mRNA levels in the kidney (D) and liver (E) of WT and KO mice. Values are mean ± standard deviation (SD; n = 4). ∗P < .05; ∗∗P < .01, as indicated.