Diagnostic workflows for SM, as suggested by McMurray et al. The presenting conditions where the diagnosis of SM should be evaluated are at the top of the figure. The additional tests needed to confirm or rule out a diagnosis of SM are shown in red at the bottom of the figure. PB and BM samples should be screened for the KIT pD816V mutation with highly sensitive techniques, such as droplet digital PCR and allele-specific oligonucleotide real-time quantitative PCR. PB, peripheral blood.