T-cell states in myeloma and healthy age-matched controls. (A) UMAP of total 690 939 T cells with annotated cell states. (B) Violin plot of normalized expression of selected representative genes for each cell state. (C) Density map of T cells from healthy controls (HCs) and patients with MM. (D) Bar plot showing proportions of each cell state in HC and MM. Significance level was determined using Wilcoxon rank-sum test (P < .001). (E) Heat map of normalized expression of selected differentially expressed genes between HC and MM. IFN, interferon; MAIT, mucosal-associated invariant T cell; NKT, natural killer T cell; Tcm, central memory T cell.