Threshold decision model analysis. The results of the threshold decision model analysis in the setting of the low bleeding risk (A) and high bleeding risk (B). The vertical lines (ASH R∗) refer to the recommendations 1 to 6 by the ASH thrombophilia panel. Theoretical thresholds above or below which treatment vs thrombophilia testing vs no anticoagulant treatment should be given are denoted by P_tt, P_t, and P_rx, respectively (see equations 1-3). Note that because all ASH R lines are to the right side of P_rx that is, larger than the treatment threshold P_rx in a low-risk bleeding scenario, offering indefinite anticoagulant treatment to all patients represents the best management strategy (A). The same holds for ASH R1, R3 to R5, and R6 in the setting of high-risk bleeding. Because the vertical line ASH R2 is to the left, that is, lower than P_tt (test–no treatment threshold), discontinuing anticoagulation after 3 months of treatment after VTE due to surgery is recommended (see manuscript for details, Table 3, R2).