OS by best response on treatment. Kaplan-Meier estimates of survival by best response observed on treatment. The x-axis shows the time from start of treatment. The legend shows the median OS (mOS) and HRs in comparison with NR. ∗P < .0001 for comparison with NR adjusting for drug, baseline TI status, baseline ECOG performance status, age group, and prior HSCT. See supplemental Table 3 for details. ECOG, Eastern Cooperative Oncology Group; HSCT, hematopoietic stem cell transplantation.