Residual hemostatic activity in platelet-poor plasma of f10^low mice. (A-B) One-stage clotting assays, PT (A) and activated partial prothrombin time (aPTT) (B) were performed using plasma of pI:pC–treated f10^WT mice (n = 8) and f10^low mice (n = 8). Horizontal lines represent mean values. Statistical analysis was performed using unpaired Student t test. (C-D) Thrombin generation was performed using TF (C) or FXIa (D) as initiator. Solid lines represent median values, and colored areas indicate interquartile range. Blue: f10^WT mice and red: f10^low mice. Number of measurements are indicated for each condition. Detailed values of thrombin generation parameters (lag time, ETP, thrombin peak, and time to peak) are summarized in Table 1.