Figure 2.
![ILD can occur when lung macrophages ingest ADCs containing trastuzumab. (A) The ADCs are bound to circulating cancer cells (CCs) and are removed from the cells by LMs via trogocytosis. The LMs are killed by the ADC payload. This reaction can also lead to the killing of neutrophils, which can mediate trogocytosis of trastuzumab-opsonized cells.75-81,85 (B) Soluble ICs composed of ADCs containing trastuzumab and the extracellular domain of HER2 (Antigen [Ag]) can be taken up by LM. Again, the LMs are killed by the ADC payload.92-96 LM, lung macrophage. Figure created with BioRender.com.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/144/2/10.1182_blood.2024024442/2/blood_bld-2024-024442-gr2.jpeg?Expires=1756140689&Signature=JmitF3S2OCU3tilW-0sPFTJ647hAudz9zl2S9qSgoko0IBxBe2-xUKc8yucWurqTxAtV0g32dZHAfot6vP~ch9KXuBurBykMuxkLrr622IdptVXowFw1Y6fgKAIWWUQ-6RF5-r6hFJPquJzI7sWlDQSu5~CRpxqfcBhFqpC2flfHLUrBydDjR3pUNut1kM72MNYL3FM3ELb-6XYMSu0CBSc7KU5oCa~Jmp1KoiUTvf6mT8U368kUH4PF0UYwu1whxkJijA7DmOO8BNcTL5fka-ddweRpfcGFwyB3uAcNzMnfV9jRaCXzVXY~aPrZC7P9zN3xHXk0CgcBNygovq~W0g__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
ILD can occur when lung macrophages ingest ADCs containing trastuzumab. (A) The ADCs are bound to circulating cancer cells (CCs) and are removed from the cells by LMs via trogocytosis. The LMs are killed by the ADC payload. This reaction can also lead to the killing of neutrophils, which can mediate trogocytosis of trastuzumab-opsonized cells.75-81,85 (B) Soluble ICs composed of ADCs containing trastuzumab and the extracellular domain of HER2 (Antigen [Ag]) can be taken up by LM. Again, the LMs are killed by the ADC payload.92-96 LM, lung macrophage. Figure created with BioRender.com.
